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Since ancient times, the Kusanagi clan opposes the Yagami, each one of them controlling the capacity of the divine flames. The rising generation does not make departures from the rule with Kyo Kusanagi and Iori Yagami. Formerly, these two with Chizuru Kagura formed the "three instruments" who made it possible to overcome Yamata Orochi, a demon being that prevailed in time in the shape of a giant snake. The Corsican business when a called secret organization NESTS unloads clones of Kyo. The survival of humanity is once more threatened...